More Mercedes-Benz E-Class pictures
The BMW 5 Series and Audi A6 rival is based on the Concept Fascination car that was unveiled at last year's Paris motor show.
The new Mercedes is said to be bigger than the current model, improving safety and rear passenger space. Boot capacity will also be up on the current saloon's 550 litres.
A range of more fuel-efficient engines is expected to power the car, ranging from a 163bhp 1.8-litre petrol to a 388bhp 5.5-litre V8.
The engine line-up is also expected to be revamped with even more efficient direct-injection and twin-turbocharged units by 2011.
The saloon and Coupe versions are due to go on sale this summer, with an estate model due to arrive in October.